In the summer of 2010, Mourinho ascended to the throne of Real Madrid under the name of "Madman". At that time, Real Madrid captain Raúl and vice-captain Guti left the team, and Casillas took over the captaincy. 2010-2011 season, Casillas led Real Madrid to win the Copa del Rey after 18 years, and broke the curse of six consecutive years of not being able to get to the last eight of the Champions League. 2011 Casillas was honored as the best goalkeeper of the year in the international field, and also named in the best team of the international soccer league and the best team of the UEFA.
In the 2011-2012 season, Casillas led Real Madrid to regain the La Liga title after three seasons, which was his fifth career La Liga title and the first time he led a team to win the title as captain. Remarkably, in the first round of that season's La Liga national derby, Real Madrid lost 1-3 at home to Barcelona, and Casillas created an embarrassing record as the goalkeeper who conceded the most goals in the history of national derbies. However, 2012 was a successful year for Casillas, who once again led Spain to the European Cup as captain. From Euro 2008 to the 2010 International Cup, and then to Euro 2012, Spain accomplished the feat of three consecutive titles in major competitions.
In Euro 2012, Casillas held on to his record of 509 consecutive minutes without conceding a goal, breaking the longest consecutive shutout streak in the final round of the European Cup held by Italy's legendary goalkeeper Zoff. During the three consecutive championships, Casillas led the Spanish back line in the screening stage did not lose a goal. 2012, Casillas with excellent performance, was once again named the best international goalkeeper, becoming the first goalkeeper in history to win this award for five consecutive years. It is worth mentioning that in the European Cup final, Casillas and old rival Buffon once again staged a goalkeeper duel, the final winner is Casillas, after the match, the two shook hands, Buffon on Casillas commented: "To be honest, I don't need too many words to describe how good he is, the result is there for all to see. He has won everything he can and has remained at a high level for so many years, which is probably the most difficult for a goalkeeper. Spain have almost never conceded a goal, mainly thanks to the fact that they have Casillas."
In the 2012-2013 season, Casillas was at odds with then Real Madrid manager Jose Mourinho. on December 22, 2012, in Real Madrid's 2-3 away defeat to Malaga, Casillas was rarely dropped to the bench by Mourinho due to locker room and athletic issues, which is considered the beginning of a series of rivalry disputes between Casillas and Mourinho. News of Real Madrid's internal rivalry was exposed by the media at the time, with some of what was going on in the dressing room, allegedly passed on to the press by Casillas through his girlfriend Sara, greatly affecting the stability of the team. At the time, a Radio Marca reporter, Mayana, claimed that Real Madrid goalkeeper coach Silvino Lolo was Mourinho's eyes and ears planted beside the players, and that Silvino Lolo would even report what the players had said to Mourinho, resulting in Real Madrid players not daring to speak up in front of Silvino Lolo. Once this inside story was exposed, Mourinho was very angry about it.
In the league round before Mourinho dropped Casillas, after Real Madrid's home game against Espanyol, Real Madrid officials took Maiana to a room because Mourinho and Silvino Lolo wanted to talk to him. What later happened in this room was all revealed by Meyana to Spanish media outlet As, where Meyana said, "When I entered the room, Silvino Lolo immediately reprimanded me, questioning my honesty and even shouting angrily at me to reveal the source of the information." In other words, Silvino Lolo wanted to know who was the "mole" in the locker room and who was revealing things about the team to Maiana, who, of course, did not disclose them. And another media confidential newspaper reported that the Real Madrid staff brought Mayana into the room, Mourinho also brought two security guards into the room, after Mayana into the room, Mourinho implied that the security guards immediately lock the door, this time the emotional outburst of Mourinho scolded Mayana is a stinking shit.
Immediately following Real Madrid's away match against Malaga, starting goalkeeper Casillas was dropped. The media on Mourinho's decision to use very surprised, although Mourinho emphasized that Casillas is due to poor performance, so by the number two goalkeeper Adan debut, but the outside world do not agree with Mourinho's statement, because at that time Casillas did not have injuries, and do not need to be rotated, the two are sure to produce a contradiction. The Spanish media As pointed out that Mourinho identified Casillas as one of the team's "mole", and therefore punished the captain of Real Madrid, put him on the bench. It is reported that after Mourinho learned that some players will be the team's internal things to the media, Mourinho is ready to crack down on Casillas.
After the outbreak of the "mole" incident, some Real Madrid fans therefore have a change of opinion on Casillas, they gave Casillas a nickname "topor", topor is a combination of topo and portero, in Spanish In Spanish, topor is a combination of topo and portero, meaning "mole" and "goalkeeper" respectively, and "mole" also means spy in some countries. Casillas was also hit by Mourinho's crackdown, and was out of action for two months after being injured by teammate Arbeloa in a Copa del Rey match against Valencia in January 2013, injuring the metacarpal bone in his left hand. Before the winter window closed, Real Madrid introduced Diego Lopez, the "octopus brother", to replace Casillas, Diego Lopez is now playing in the main goalkeeper of Spaniards.
Diego Lopez joined Real Madrid after a stable performance, which makes Casillas also difficult to return to the starting position after injury, Mourinho also had an excuse to abandon Casillas, then Casillas sat on the bench until the end of the season, and ultimately, Real Madrid in the 2012-2013 season is no harvest, the league and the King's Cup were runner-up, the Champions League in the semi-finals eliminated out of the game, the season of the three blanks, manager Mourinho left the club at the end of the season. Although Mourinho's dismissal is mainly due to the performance of the reasons, but will not be able to solve the opponent, affecting the team's morale, which is the Real Madrid senior management do not want to see the situation, and the internal struggle between Mourinho and Casillas, and ultimately to the end of the dismissal of Mourinho.